Abstract:[Objective] To clarify whether the kinematic alignment technique improve the trajectory of the bearing movement, as well as the clinical outcomes and radiological presentations in Oxford mobile bearing unicompartmental knee arthroplasty (Oxford MB UKA) . [Methods] We retrospectively analyzed the patients who underwent UKA from January to June, 2019. Of them, 23 patients (30 knees) had UKA performed by the kinematic alignment technique (the kinematic group) , while the other 25 patients (30 knees) received UKA with the conventional alignment technique (the conventional group) . There were no significant differences in term of baseline data preoperatively be- tween the two groups. The intraoperative bearing movement mode, motion distance, clinical outcome and radiographic data were compared between the two groups. [Results] The kinematic group proved significantly superior to the conventional group in term of bearing movement trajectory (P<0.05) , despite of the fact that no a difference was noticed in the motion distance of the liner between them (P>0.05) . In terms of clinical outcomes, the kinematic group was significantly superior to the conventional group regarding to intraoperative blood loss and oper- ation time (P<0.05) , whereas there were no statistically significant differences in KSS clinical and functional scores between the two groups at any matching time point (P>0.05) . Radiographically, the hip- knee- ankle angle (HKAA) significantly decreased postoperatively com- pared with that preoperatively in both groups (P<0.05) , which was not statistically different between the two groups at any corresponding time point (P>0.05) . There were no significant differences in terms of varus-valgus angles of the femoral and tibial components, flexion-ex- tension angle of the femoral component, posterior slope of the tibial tray and relative oblique of the femoral and tibial components between the two groups (P>0.05) . However, the kinematic group got significantly closer contiguity of the components than the conventional group (P< 0.05) . [Conclusion] Although the kinematic technique does achieve similar prosthetic installation accuracy and clinical outcome with the conventional technique for Oxford MB UKA, the former has advantages of less blood loss, shorter operation time, closer contiguity of the fem- oral and tibial components, and more optimal bearing movement trajectory over the latter.