不同支架间充质干细胞治疗膝骨性关节炎现状△

Current researches on different scaffolds with mesenchymal stem cells for treatment of knee osteoarthritis

摘要:

膝骨性关节炎(knee osteoarthritis, KOA)是一类以软骨退变剥脱为主要特征的退行性骨关节疾病，在世界各国发病率均较高。目前治疗 KOA 主要采用阶梯治疗，近年来以间充质干细胞(mesenchymal stem cells, MSCs)为代表的软骨再生疗法的研究较多。但单纯使用 MSCs 进行关节腔注射后存在存活率与分化率较低的缺点，因此使用适当的支架对 MSCs 进行搭载意义重大。本文将对不同支架搭载的 MSCs 治疗 KOA 研究进行综述。

Abstract:

Knee osteoarthritis (KOA) is a kind of degenerative joint diseases mainly characterized by cartilage degeneration and loss. The incidence of KOA is high in all countries around the world. Currently, step therapy is the main strategy for KOA, among which cartilage regeneration therapy represented by mesenchymal stem cells (MSCs) has been widely studied in recent years. However, there are disadvan- tages of low survival rate and differentiation rate after joint cavity injection of MSCs alone. Therefore, it is of great significance to use appro- priate scaffolds to carry MSCs. This article will review the current treatment of KOA with MSCs embedded on different scaffolds.