雌激素及其受体在骨关节炎中的研究进展△

Research progress on estrogen and estrogen receptors in osteoarthritis

摘要:

骨关节炎是中老年常见的慢性关节病，在绝经后妇女中发病率最高，提示该疾病应与绝经后雌激素水平的变化密切相关。雌激素及其受体在代谢机制中发挥多种作用，通过多种途径涉及关节软骨和软骨下骨的细胞增殖和凋亡，这成为绝经后女性骨关节炎高发的有力论据。目前，虽然关于雌激素及其受体代谢与骨关节炎相关性的研究并不缺乏，但最新的统一讨论仍然很少。因此，本文从雌激素及其受体影响经典 Notch 信号通路和胰岛素样生长因子、白细胞介素 1 β、基质金属蛋白酶等软细胞代谢调节关节的共同机制，综述了雌激素及其受体与骨关节炎的关系。为今后进一步可能的研究方向提供参考。

Abstract:

Osteoarthritis, a common chronic joint disease in the middle-aged and the elderly with the highest incidence in the post- menopausal women, has been suggested that this disease should be closely related to the changes of postmenopausal estrogen levels. Estro- gen and its receptors play many roles on metabolic mechanisms, involving cell proliferation and apoptosis of articular cartilage and subchon- dral bone by multiple ways, which has become a strong argument for the high incidence of osteoarthritis in postmenopausal women. At pres- ent, although there is no lack of studies on the correlation of estrogen and its receptor metabolism with osteoarthritis, the latest unified dis- cussion on this topic remains rare. Therefore, this paper reviews the relationship of estrogen and its receptors with osteoarthritis by the com- mon mechanism, such as estrogen and its receptors influencing the classic Notch signal channel and insulin-like growth factor, interleukin 1 beta, matrix metalloproteinases and other soft cell metabolism regulation of joint mechanism, to provide a reference for the future possible research direction further.