Abstract:[Objective] To explore the initial results of transtheoretical model (TTM) in the rehabilitation of primary unilateral total knee arthroplasty (TKA) . [Methods] From January 2021 to June 2021, a total of 123 patients who were undergoing TKA were randomly di- vided into two groups by lotting. All patients received primary unilateral TKA, of them, 63 patients were given perioperative TTM interven- tion, while the other 60 patients received conventional rehabilitation intervention. The self-management ability, knee function and quality of life were compared between the two groups. [Results] In terms of self-management ability, the SMAS scores in both groups increased sig- nificantly after intervention compared with those before intervention (P＜0.05) , and the TTM group proved significantly superior to the con- ventional group in all subscores of SMAS after intervention (P＜0.05) . In terms of knee function, HSS scores increased significantly over time in both groups (P＜0.05) , which in TTM group was significantly higher than that in conventional group at 1 and 3 months after opera- tion (P＜0.05) . In terms of quality of life, the GQOLI-74 scores were significantly increased in both groups after intervention in comparison of those before intervention (P＜0.05) , and all subscores of GQOLI-74 in TTM group were significantly higher than those in conventional group after intervention (P＜0.05) . [Conclusion] The rehabilitation intervention enhanced by transtheoretical model does effectively im- prove patients' self-management ability, promote the recovery of knee function and improve the quality of life.