核因子E2相关因子2在椎间盘退变中的作用△

Role of nuclear factor E2 related factor 2 in intervertebral disc degeneration

摘要:

椎间盘退变(intervertebral disc degeneration, IDD)是一种临床常见的肌肉骨骼系统退行性疾病，大约 70%~85%的人一生中至少会经历一次腰痛，严重影响患者的生活质量，给家庭带来沉重的经济负担。目前，IDD 的具体发病机制尚不完全清楚。核因子 E2 相关因子 2(Nuclear factor E2 related factor 2, Nrf2)是调控细胞氧化应激反应的重要转录因子，同时也是维持细胞内稳态的中枢调节者。研究表明，Nrf2 受到非编码 RNA (noncodingRNAs, ncRNAs) 的调控，通过抑制氧化应激，抑制炎症反应，改善线粒体功能等作用，缓解 IDD 的进展。本文就 Nrf2 的结构及其在 IDD 中的作用进行综述，以期为后续相关研究提供参考。

Abstract:

Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the musculoskeletal system. About 70% to 85% of people will experience low back pain at least once in their life span, which seriously affects the quality of life of patients, and brings a heavy financial burden to their families. However, the specific pathogenesis of IDD is not fully understood currently. Nuclear factor E2 related factor 2 (Nrf2) is an important transcription factor that regulates the oxidative stress response of cells, and maintains cell homeo- stasis as a central regulator. Current studies have shown that Nrf2 can inhibit oxidative stress, inhibit inflammation, improve mitochondrial function, etc., on the other hand, Nrf2 is regulated by noncoding RNAs (ncRNAs) to alleviate the progress of IDD. This article reviews the structure of Nrf2 and its role in IDD to provide a reference for following related research.