Abstract:[Objective] To compare biomechanical characteristics of a novel pedicle screw (NPS) with the traditional pedicle screw (TPS) , TPS combined with transvers link (TPS-T) and TPS enhanced by bone cement (TPS-C) by finite element method. [Methods] The lumbar CT scan data of volunteers were obtained, and the L4/5 vertebral body model was established by Mimics, UG and Abaqus software. On this basis, the NPS, TPS, TDS-T and TDS-C fixation models were established respectively. In 6 degrees of freedom, including flexion, extension, left and right lateral bending, left and right rotation, the segmental range of motion (ROM) , von Mises stress on the screw and bone around screw tract were compared among 4 groups. [Results] In terms of flexion, extension, left lateral bending and right bending, there were no significant differences in ROM, screw von Mises stress and bone von Mises stress between NPS group and the other three groups (P＞0.05) . In terms of left and right rotations, the NPS group had ROM, screw von Mises stress and bone von Mises stress significant- ly lower than the other three groups (P＜0.05) , whereas the TPS group had ROM, screw von Mises stress and bone von Mises stress signifi- cantly higher than the other three groups (P＜0.05) . There was no significant difference in ROM and screw von Mises stress between TPS-T group and TPS-C group (P＞0.05) , but the TPS-T group had bone von Mises stress significantly lower than that in TPS-C group (P＜0.05) . [Conclusion] The NPS has considerably lower ROM, screw von Mises stress and bone von Mises stress than the 3 types of TPS, which might be facilitated to reduce the screw loosening.