Abstract:[Objective] To investigate the clinical outcomes of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF)for degenerative spondylolisthesis (DS) . [Methods] A retrospective study was conducted on a total of 101 patients who were admitted to ourhospital from April 2016 to December 2018 for single-segment DS. According to doctor-patient communication results, 53 patients under-went MIS-TLIF (MIS group) , while the other 48 patients underwent open TLIF surgery (open group) . The perioperative, follow-up and im-aging data of the two groups were compared. [Results] All patients in both groups had operation performed successfully without a signifi-cant difference in the operation time between the two groups (P＞0.05) . However, the MIS group proved significantly superior to the opengroup in terms of total incision length, intraoperative blood loss, postoperative drainage, time to resume ambulation and hospital stay (P＜0.05) . As time went during follow up period lasted for (28.32±9.65) months on average, the VAS and ODI scores decreased significantly inboth groups (P＜0.05) . There was no significant difference in VAS score between the two groups at 6 months after surgery and the latest fol-low-up (P＞0.05) , but ODI score of MIS group was significantly better than that of the open group at the latest follow-up (P＜0.05) . Radio-graphically, the intervertebral space height increased significantly (P＜0.05) , whereas the percentage of vertebral slippage significantly de-creased in both groups postoperatively compared with those preoperatively (P＜0.05) . At any corresponding time points, there was no statis-tically significant differences in the above image indexes between the two groups (P＞0.05) . [Conclusion] Minimally invasive transforami-nal lumbar fusion has benefits of minimizing iatrogenic trauma and facilitating postoperative recovery over the open counterpart for singlespace degenerative lumbar spondylolisthesis.