中老年男性Ⅱ型糖尿病骨密度与血压的相关研究

Correlation between lumbar bone mineral density and blood pressure in elderly males with type II diabetes mellitus

摘要:

［目的］ 探讨Ⅱ型糖尿病 （type 2 diabetes mellitus, T2DM） 患者不同血压水平对骨密度 （bone mineral density, BMD） 的影响，并分析其他可能影响该部分人群 BMD 的因素。［方法］ 2019 年 4 月—2020 年 10 月在本院住院的 99 名中老年男性 T2DM 患者纳入本研究，收集相关资料，检测血压、骨密度和血脂，分组行单因素比较，Pearson 相关分析以及多元回归分析。 ［结果］正常血压组和轻度高血压组的 L_1~4BMD 均显著高于中度高血压组（P<0.05），但是三组间其他资料，包括一般资料、实验室检验结果的差异均无统计学意义（P>0.05）。99 例患者资料 Pearson 相关分析表明，腰椎 BMD 与收缩压呈显著负相关（P< 0.05），与 LDL-c 呈显著正相关 （P<0.05），与吸烟时长呈显著负相关 （P<0.05）。多元逐步回归表明， LDL-c （B=0.039，P< 0.05），收缩压 （B=-0.003，P<0.05），吸烟时长 （B=-0.002，P<0.05） 是影响 BMD 的因素。［结论］ 对于中老年男性 T2DM 患者，血压控制在较低水平更有利于骨质健康。

Abstract:

[Objective] To explore the impact of blood pressure levels on bone mineral density (BMD) in elderly males with type II dia- betes mellitus (T2DM) , and analyze other factors that may influence BMD in this population. [Methods] A total of 99 middle-aged and el- derly males who were hospitalized for T2DM in our hospital from April 2019 to October 2020 were enrolled into this study. Data regarding to general states and disease history were collected, blood pressure, bone mineral density and blood lipids were measured. Univariate com- parison among different groupings, Pearson correlation and multiple regression were conducted. [Results] L_1~4 bone mineral density (BMD) in the normal blood pressure group and mild hypertension group was significantly higher than that in moderate hypertension group (P＜ 0.05) , but there were no significant differences in other general data and laboratory test results among the three groups (P＞0.05) . As re- sults of Pearson correlation analysis of 99 patients, the lumbar BMD was significantly negatively correlated with systolic blood pressure (P＜ 0.05) , positively correlated with LDL-C (P＜0.05) , and negatively correlated with smoking duration (P＜0.05) . In term of stepped multiple regression, LDL-c (B=0.039, P＜0.05) , systolic blood pressure (B=-0.003, P＜0.05) , smoking duration (B=-0.002, P＜0.05) were the factors related to BMD. [Conclusion] For middle-aged and elderly males with T2DM, controlling blood pressure at a lower level is more benefi- cial to bone health.