Abstract:[Objective] To compare the clinical efficacy of two minimally invasive procedures, unilateral biportal endoscopic discectomy (UBE) and minimally invasive tubular discectomy (MITD). [Methods] From August 2020 to August 2021, a retrospective review was performed in 166 patients who had underwent either UBE or MITD at Yantai Mountain Hospital in Yantai City. According to the consequences of preoperative doctor-patient communication, 50 patients underwent UBE and 116 patients underwent MITD. The perioperative, follow-up and radiographic documents were compared between the two groups. [Results] The operation time was longer in the UBE group than in the MITD group, and the difference was statistically significant (P<0.05). The incision length, number of intraoperative fluoroscopies, intraoperative blood loss, and hospital stay were significantly better in the former than in the latter (P<0.05). The former was better than the latter in time to floor and incision healing, but the difference between the two groups had none statistical significance (P>0.05).Patients were followed up for 12-24 months with a mean of (15.73±3.54) months. The time to full weight-bearing activity was obviously shorter in the UBE group than the MITD group, and the difference between the two groups had none statistical significance (P>0.05). Postoperatively, the VAS and ODI scores decreased significantly at time in both groups (P<0.05). The differences in VAS and ODI scores between the two groups at the corresponding time points had none statistical significance (P>0.05). Compared with the preoperative period, the postoperative disc height and the percentage of occupied area of the spinal canal were significantly decreased in both groups (P<0.05), but the differences in imaging indexes between the two groups at the corresponding time points had none statistical significance (P>0.05). [Conclusion] The application of UBE for single-segment lumbar disc disease can achieve similar clinical outcomes as MITD, but UBE is less invasive, has fewer intraoperative fluoroscopic views, and further reduces hospital stay.