TUG1在骨肉瘤发病中的作用的研究进展△

Research progress on the role of TUG1 in pathogenesis of osteosarcoma

摘要:

牛磺酸上调基因 1 (taurine upregulated 1, TUG1) 是一种长链非编码 RNA (long non-coding RNA, lncRNA)，其通过复杂的分子机制参与骨肉瘤的发生发展。TUG1 通过抑制多种 miroRNA (miRNA)和调节相关信号通路，促进骨肉瘤细胞的增殖、侵袭和转移，抑制骨肉瘤细胞的凋亡。此外，TUG1 的表达水平与骨肉瘤患者的预后相关，是一种判断预后的潜在生物标志物。本文旨在总结近年来的相关研究，对 TUG1 参与骨肉瘤细胞增殖、凋亡、侵袭和转移的相关分子机制以及 TUG1 在骨肉瘤中的临床意义的研究进展做一综述。

Abstract:

Taurine upregulated gene 1 (TUG1) is a long non-coding RNA (lncRNA) , which involves in the occurrence and develop- ment of osteosarcoma by complex molecular mechanisms. It can promote the proliferation, invasion and metastasis, and inhibit the apopto- sis of osteosarcoma cells by inhibiting some miroRNAs (miRNAs) and regulating related signal pathways. In addition, the expression level of TUG1 is related to the prognosis of osteosarcoma, therefore, TUG1 is a potential biomarker for prognosis. In this paper, by summarizing related studies in recent years，we review the molecular mechanisms of proliferation, apoptosis, invasion and metastasis in osteosarcoma cell mediated by TUG1 and the clinical value of TUG1 in osteosarcoma.