Abstract:[Objective] To investigate the effect of intraoperative cervical curvature adjustment by a self-developed instrument in anteri- or cervical discectomy and fusion (ACDF) on the clinical and radiographic consequences. [Methods] From January 2020 to March 2021, 36 patients underwent ACDF with intraoperative cervical lordotic curvature adjustment by the self-developed instrument. The postoperative out- comes, involving clinical and imaging parameters, were observed and compared. [Results] All patients were successfully operated on with- out serious complications, and got significant improvement in clinical symptoms gradually postoperatively. The JOA scores increased signifi- cantly (P<0.05) , whereas the NDI and VAS scores decreased significantly over time (P<0.05) . Radiographically, overall lordotic curvature (C2~C7 Cobb angle) and segment lordotic curvature (local Cobb angle) were significantly increased after the intraoperative curvature adjust- ment, implant placement, and 3 days before discharge compared with those before operation and after anesthesia (P<0.05) . After that, over- all lordotic curvature and segment lordotic curvature tended to be lost again in some extent during the following time points in the follow-up period, but which were not statistically significant (P>0.05) . [Conclusion] This intraoperative adjustment of cervical curvature during ACDF by the self-developed instrument does maintain, even improve the postoperative overall and segmental curvature of cervical spine.