血清标志物与股骨头坏死骨密度和骨钙素的关系

Relationship between serum markers and bone density or osteocalcin in femoral head necrosis

摘要:

［目的］ 探讨血清Ⅰ型胶原 C 端肽 （CTX）、1 型纤溶酶原激活物抑制剂 （PAI-1） 及白介素 33 （IL-33） 与股骨头坏死患者骨密度 （BMD）、骨钙素 （BGP） 之间的相关性。［方法］ 2017 年 1 月—2020 年 1 月，本院接诊的 95 例股骨头坏死患者，设为坏死组；同期体检健康者 80 例作为正常人组。检测血清 CTX、PAI-1、IL-33，BGP 和 BMD，分析血清标志物与 BMD 和 BGP 的相关性。［结果］ 坏死组患者血清 CTX、PAI-1、IL-33、BGP 水平以及 BMD 显著高于正常人组 （P<0.05）。血清 CTX、PAI-1 及 IL-33 均与 BMD 呈显著正相关 （P<0.05），血清 CTX、PAI-1 及 IL-33 均与 BGP 呈显著正相关 （P<0.05）。 ［结论］ 股骨头坏死患者血清 CTX、PAI-1 及 IL-33 的表达和 BMD、BGP 之间存在密切关系。

Abstract:

[Objective] To explore the relationship between serum markers, such as C-telopeptide (CTX) of type I collagen, plasmino- gen activator inhibitor (PAI-1) and interleukin 33 (IL-33) , and bone mineral density (BMD) or osteocalcin (BGP) in femoral head necrosis. [Methods] From January 2017 to January 2020, 95 patients with femoral head necrosis admitted to our hospital were enrolled as the necro- sis group, while 80 healthy subjects were selected as the normal group. The serum CTX, PAI-1, IL-33 and BGP, as well as BMD were de- tected, furthermore, the correlation between serum markers and BMD or BGP was analyzed. [Results] The necrosis group had significantly higher levels of serum BGP, CTX, PAI-1 and IL-33, as well as BMD than the normal group (P＜0.05) . The serum CTX, PAI-1 and IL-33 were significantly positively correlated with BMD (P＜0.05) . In addition, the serum CTX, PAI-1 and IL-33 were significantly positively cor- related with BGP (P＜0.05) . [Conclusion] The serum expressions of CTX, PAI-1 and IL-33 in femoral head necrosis are closely related to BMD and BGP.