Abstract:[Objective] The purpose of this study was to measure and analyze morphologic feature of resected distal femoral surface in normal knees between the males and females. [Methods] 187 normal knees (94 males, 93 females) were measured by computed tomography for the distal femoral mediolateral (ML), anteroposterior (AP), width of medial condyle (MCW), width of lateral condyle(LCW), Width of intercondylar fossa(WICF), Height of intercondylar fossa(HICF) and ML/AP aspect ratio to compared the differences of resected distal femoral surface between males and females. [Results] There were signi?cant morphologic differences in resected distal femoral surface between males and females (P<0.01). We found a progressively decreased in the ML/AP aspect ratio with an increasing AP dimension, and distal femoral showed same AP dimensions resulting in a higher ML/AP aspect ratio in males and a lower ML/AP aspect ratio in females. This means that under a given AP dimension prosthesis, the femoral ML dimension have the potential to be undersized in males and to overhang in females. [Conclusion] Distal femoral showed significant differences in the size and shape between males and females. The results can provide important reference in designing proper gender-specific femoral prosthesis with different ML/AP aspect ratio in future.