间充质干细胞在椎间盘退变中作用△

Role of mesenchymal stem cells in intervertebral disc degeneration

摘要:

腰背痛是临床常见疾病，近年来随着人口老龄化的加重，发病人数不断上升。研究发现椎间盘退变是引起腰背疼痛的主要原因之一，间充质干细胞具有的多能分化性、归巢及旁分泌特性能够补充椎间盘细胞并调节内部炎症反应，在修复椎间盘退变治疗腰背痛方面具有重要意义，近年来临床应用 MSC 治疗椎间盘退变取得了良好的疗效，组织工程学的发展也进一步提高了 MSC 治疗的效果及应用范围，本文通过查阅最新文献，总结了间充质干细胞在修复椎间盘退变中的作用机制以及在临床及组织工程学的研究应用进展，为腰背痛的治疗前景提供新的思路。

Abstract:

Low back pain is a common clinical disease, which in number of cases has been increasing in recent years with the aging of the population. Many studies have found that intervertebral disc degeneration is one of the main causes of low back pain. The mesenchymal stem cells with capacity of pluripotent differentiation, homing, and paracrine properties plays important roles in intervertebral homeostasis, involving regulation of internal inflammation, and repair of injuries in intervertebral disc degeneration, which has great significances for treatment of low back pain. In recent years, the clinical application of MSC in the treatment of intervertebral disc degeneration has achieved good results in some extent. The development of tissue engineering has further improved the effect and application scope of MSC treatment. This article summarizes the latest literature about mechanism of MSCs in repairing intervertebral disc, the progress in clinical and tissue en- gineering research and clinical application to provide new ideas for the treatment of low back pain.