Abstract:[Objective] To evaluate the clinical outcomes of arthroscopic release for carpal tunnel syndrome. [Methods] A retrospec- tive study was conducted on 28 patients who received arthroscopic release for carpal tunnel syndrome, including 5 males and 23 females aged from 46 to 62 years old, with a mean of (53.15±7.89) years. The Boston carpal tunnel questionnaires (BCTQ) , including functional state (FS) and symptom severity (SS) were used to evaluate the clinical outcomes, additionally, electrophysiological examinations, involving latency (Lat) and amplitude (Amp) of motor potential and sensory conduction velocity (SCV) were conducted. [Results] All the 28 patients had surgical procedures performed smoothly in 10 min with blood loss about 1 ml, while without injuries to the blood vessels, nerves and the tendons , and were followed up for 6~12 months. As time went both BCTQ-FS and BCTQ-SS significantly decreased (P<0.05) . Of them, 1 patient developed greater and lesser thenar muscle atrophy due to nerve entrapment for too long period. The clinical outcomes were marked as excellent in 26 cases, good in 1 case and fair in 1 case, with excellent and good rate of 96.77%. In term of electrophysiological examination, the Lat decreased significantly, whereas the Amp and SCV increased significantly at the latest follow-up compared with those preoperatively (P<0.05) . [Conclusion] The arthroscopic release of carpal tunnel syndrome has an advantage of smaller trauma, does achieve considerably satisfactory clinical outcomes.