Abstract: [Objective] To compare the clinical outcomes of locking proximal humeral plate (LPHP) versus cannulated screw (CS) fixa- tion for the treatment of glenohumeral dislocation accompanied with humeral greater tuberous fracture. [Methods] From January 2016 to March 2019, 76 patients received open reduction and internal fixation for treatment of glenohumeral dislocation accompanied with humeral greater tuberosity fracture in our hospital. According to the surgical indications, 40 patients were treated with LPHP, while the other 36 pa- tients were with CS. The clinical and imaging consequences were compared between the two groups. [Results] All patients in both groups were operated on successfully without serious complications. The CS group proved significantly superior to LPHP group in terms of opera- tive time, total incision length and intraoperative blood loss (P<0.05) . All patients in both groups were followed up for (18.84±4.31) months on an average. Compared with those 3 months after surgery, the VAS score significantly decreased (P<0.05) , while the abduction and for- ward flexion range of motion (ROM) , as well as Constant-Murley score significantly increased in both groups at the latest follow up (P< 0.05) , additionally, which in the CS group was significantly superior to the LPHP group at 3 months after the operation (P<0.05) . Radio- graphically, the excellent reduction rate in the CS group (61.11%) was significantly higher than that in the LPHP group (52.50%) (P<0.05) . However, there was no significant difference in the fracture healing time between the two groups (P>0.05) . [Conclusion] Both the methods are effective treatment for glenohumeral dislocation accompanied with humeral greater tuberosity fractures, by comparison, the cannulated screw fixation has a benefit of minimizing iatrogenic trauma.