缺氧诱导因子1α介导椎间盘退变的研究进展△

Research progress in hypoxia-inducible factor 1α mediated intervertebral disc degeneration

摘要:

腰背痛 (low back pain, LBP) 是骨科最常见的病症，造成了巨大的社会经济压力。腰椎椎间盘退变 (intervertebral disc degeneration, IDD) 是导致腰背痛的重要因素，但其具体机制仍需深入研究。研究认为缺氧诱导因子 1α (hypoxia inducible factor 1α, HIF1α)广泛参与调控 IDD 的病理过程，是导致 IDD 发生与发展的重要基因之一。本文对既往文献报道中关于 HIF1α 在 IDD 中的研究进行归纳分析，总结 HIF1α 介导椎间盘退变的研究进展，重点探讨 HIF1α 在 IDD 中的潜在作用及机制，并预测发展趋势。

Abstract:

Low back pain (LBP) is one of the most common disorders met in orthopaedic practice worldwide, resulting in severe soci- etal burden. It is believed highly associated with progression of intervertebral disc degeneration (IDD) , whereas its mechanism still needs to be further studied. In recent years, it has been shown that hypoxia inducible factor 1α (HIF1α) , one of the important genes leading to the occurrence and development of IDD, is widely involved in regulating the pathological process. In this paper, we review the progress of HIF1α role in IDD in previous studies, and summarize the potential mechanisms and research trends in focus.