Abstract:[Objective] To explore the clinical outcomes of low- profile plate fixation combined with rotator cuff anchoring for splittype humeral greater tuberosity fractures. [Methods] From June 2017 to June 2019, 34 patients underwent surgical treatment for split-type humeral greater tuberosity fractures in our hospital. The patients who had glenohumeral dislocation of joint were treated with manual reduc- tion immediately after admission, and all of them received open reduction and internal fixation with low-profile plate and suture anchoring of rotator cuff through anterior middle deltoid splitting approach. [Results] All patients had operation completed successfully, with an opera- tion time of (86.56±10.37) min, intraoperative blood loss of (72.44±12.42) ml, and primary incision healing, whereas without iatrogenic nerve and vascular injury. As time went during the follow-up lasted for (14.48±2.36) months, the VAS score significantly decreased (P< 0.05) , while Constant-Murley score significantly increased (P<0.05) . No adverse imaging manifestations, such as subacromial impinge- ment, delayed fracture union, and loosening of the implant were noted in anyone of them. [Conclusion] This low-profile plate and rotator cuff anchoring are an effective treatment for split humeral greater tuberosity fractures.