间充质干细胞外泌体对软骨修复作用的研究进展△

Research progress of mesenchymal stem cell derived exosomes on repairing articular cartilage defects

摘要:

关节软骨缺损是骨科常见疾病，治疗不佳往往会进一步加重发展成为骨关节炎。既往大量研究表明，间充质干细胞在关节软骨缺损的修复中起重要作用，但具体机制仍不完善。近年来研究发现多种由间充质干细胞分泌的外泌体在抗炎、免疫调节和细胞修复等方面起到重要作用。本文对不同间充质干细胞来源的外泌体对关节软骨缺损的修复作用及其临床转化相关的外泌体组织工程技术进行综述，为后续研究提供参考。

Abstract:

Articular cartilage defect is a common condition met in orthopedic practice, and improper treatment of it often further aggra- vates the development of osteoarthritis. A large number of previous studies have shown that mesenchymal stem cells play an important role in the repair of articular cartilage defects, but the specific mechanism remains incomplete. In recent years, studies have found that a variety of exosomes secreted by mesenchymal stem cells play an important role in anti-inflammatory, immune regulation and cell repair. This arti- cle reviews the repair effects of exosomes derived from different mesenchymal stem cells on articular cartilage defects and their clinical transformation-related exosome tissue engineering techniques to provide references for further research.