Abstract:[Objective] To introduce the surgical technique and primary clinical outcomes of free thinned sensate anterolateral thigh perforator flap for repair of large tissue defect on the foot and ankle. [Methods] A total of 9 patients received free thinned sensate anterolat- eral thigh perforator flap for repair of large tissue defect on the foot and ankle. Color ultrasound was conducted to localize the vascular ves- sels and nerves before surgery. During harvesting the graft, the proximal side of the flap was cut firstly, and then the lateral femoral cutane- ous nerve and perforating vessels were dissected, finally the distal edge was cut to complete dissociation, Subsequently, the fat tissue was trimmed until the thickness of the flap achieved 5~8 mm. The free flap was covered wound on foot and ankle, and anastomose the blood ves- sels and nerves. [Results] All the 9 patients had the flap survived and were followed up for 10~60 months. At the last follow-up, the num- ber of mono-filar tactile discrimination and blunt acute pain discrimination was lower than that of the healthy side (P<0.05) . However, the recovery of tactile sensation and acute pain sensation in the central part of the flap was significantly better than that in the surrounding area (P< 0.05) . The Vancouver scar score in the donor area was of (4.78±1.48) . [Conclusion] The free thinned sensate anterolateral thigh perfo- rator flap for repair of large tissue defect on the foot and ankle has advantages of relatively moderate donor side morbidity, sufficient sensory recovery of the skin, proper size of recipient foot matching with the opposite side to permit the painless walking with ordinary shoes wearing.