Abstract:[Objective] To report the clinical results of oblique lateral interbody fusion (OLIF) for treatment of degenerative scoliosis ac- companied with a single-segment spinal stenosis. [Methods] From August 2016 to December 2018, OLIF was performed on 18 patients with degenerative scoliosis accompanied with single-segment spinal canal stenosis. The clinical and imaging documents of the 18 patients were summarized. [Results] All the patients had the operations completed successfully, without serious complications, such as nerve and blood vessel damages. All patients were followed up for 12~24 months, with an average of (16.32±3.72) months. Compared with those preop- eratively, the VAS and ODI scores decreased significantly at the latest follow-up (P<0.05) . In terms of imaging assessment, the height of the responsible intervertebral space and foraminal area increased significantly at the last follow-up (P<0.05) ; while the Cobb angle of sco- liosis decreased, but without a statistically significant difference, compared with those preoperatively (P>0.05) . Within 16 weeks after sur- gery, all patients achieved intervertebral fusion. [Conclusion] OLIF does effectively relieve the nerve root compression or irritation caused by a single-segment spinal canal or nerve root canal stenosis in degenerative scoliosis, with minimalized surgical trauma and satisfactory clinical results.