Abstract:[Objective] To explore the clinical outcomes of tarsal sinus approach for open reduction and internal fixation (ORIF) of cal- caneal fractures involving subtalar articular surface. [Methods] From June 2017 to June 2020, a total of 24 patients (26 feet) received ORIF with plate and screws through tarsal sinus approach for acute closed calcaneal fractures involving subtalar articular surface. The clinical and imaging results were evaluated. [Results] All patients were successfully operated on without serious complications, with operative time of (53.27±2.48) min, intraoperative blood loss of (22.35±2.10) ml, and incision healing well. At the latest follow up lasted for (14.33±7.27) months on average, both active dorsal flexion range of motion (ROM) and plantar flexion ROM on the affected side were lower than those on the healthy side, whereas which was not statistically significant (P>0.05) . According to AOFAS score, the clinical outcome was marked as excellent in 16, good in 8 and fair in 2 feet, with the excellent and good rate of 92.31%. Radiographically, the B?hler and Gissane angles significantly increased (P<0.05) , calcaneal width significantly decreased (P<0.05) , calcaneal height increased significantly (P<0.05) , whereas calcaneal length remained unchanged at the latest follow up compared with those preoperatively (P>0.05) . [Conclusion] The tar- sal sinus approach for open reduction and internal fixation with plate and screws does achieve satisfactory clinical outcomes for calcaneal fractures involving subtalar articular surface.