Abstract:[Objective] To explore the role of medial collateral ligament (MCL) and radial head (RH) on elbow valgus stability, and to evaluate the outcomes of MCL repair and RH fracture fixation alone or in combination. [Methods] Six adult cadaveric bone-ligament speci- mens were treated and measured successively as follows: intact specimens, MCL cutting, MCL repair, MCL cutting +RH fracture, MCL re- pair +RH fracture, MCL cutting +RH fixation, MCL repair +RH fixation and MCL repair +RH resection. The valgus angular displacement (VAD) was measured under 1.5 N · m valgus loading at 0°~120° flexions of the elbow. [Results] The VAD at 0° of elbow flexion ranked down-up as follows: intact specimen < MCL repair +RH fixation < MCL repair < MCL repair +RH fracture < MCL repair +RH resection < MCL cutting < MCL cutting +RH fixation < MCL cutting +RH fracture, with statistically significant overall difference (P<0.05) . In term of pairwise comparison, there was no significant difference in VAD between intact specimens, MCL repair, MCL repair +RH fixation, MCL re- pair +RH fracture, MCL repair +RH resection (P>0.05) , but the above 5 groups had significantly less VAD than MCL cutting, MCL cutting + RH fixation and MCL cutting +RH fracture group (P<0.05) . As results of factorial design analysis of variance, there were statistically signifi- cant differences in VAD among the 8 specimen treatments (Ftreat= 227.670, P<0.01) , statistically significant differences in VAD among 5 de- grees of elbow flexions (Fflexion = 13.170, P<0.01) , and significant interaction between specimen treatments and flexions of the elbow (Finter = 6.143, P<0.01) . [Conclusion] MCL injury does lead to elbow valgus instability, which is considerably deteriorated by accompanied RH fracture. MCL repair alone is superior to RH fracture fixation alone to restore valgus stability.