脂代谢紊乱与椎间盘退变的关系研究进展

Research progress on relationship between lipid metabolism disorder and intervertebral disc degeneration

摘要:

椎间盘退行性变(inter-vertebral disc degeneration, IVDD)是一种慢性、发病率高、治疗费用昂贵、易复发的退变性疾病。目前对于 IVDD 的病因和发病机制仍不清楚，至今尚无有效的治疗方法。近期研究表明，除了异常、过度的机械负荷和炎症外，脂代谢紊乱可能是 IVDD 的重要病因。研究表明除了体重本身对椎间盘退变的力学影响，脂代谢紊乱来源的蛋白质、 脂肪因子和多种脂质介质，如脂肪酸，氧化低密度脂蛋白、瘦素等与 IVDD 密切相关。本综述的目的是总结有关脂代谢紊乱及相关产物与 IVDD 发病机制之间相互关系的最新发现，特别强调脂质和脂肪因子的作用并探究脂代谢紊乱致椎间盘退变的具体机制。

Abstract:

Intervertebral disc degeneration (IVDD) is a chronic degenerative disease and prone to recurrence with high incidence and expensive treatment burden. Up to now the etiology and pathogenesis of IVDD remain unclear without effective treatment in some extent. Recent evidences show that in addition to abnormal and excessive mechanical load and inflammation, lipid metabolism disorder may be an important cause of IVDD. Beside the mechanical effect of body weight on intervertebral disc degeneration, adipokines, the lipid mediators derived from lipid metabolism disorders, including fatty acids, oxidized low-density lipoproteins and leptin, are closely related to IVDD. The purpose of this review is to summarize the latest findings on the relationship between lipid metabolism disorders and related products and their role in pathogenesis of IVDD, with particular emphasis on the role of lipids and adipokines and to explore the specific mechanism of intervertebral disc degeneration caused by lipid metabolism disorders.