Abstract:[Objective] To evaluate the clinical efficacy of vertebroplasty combined with pedicle screw fixation for stage III Kümmell’s disease. [Methods] From 2016 to 2020, a total of 30 patients received vertebroplasty combined with pedicle screw fixation for stage III Kümmell’s disease. The clinical and imaging data were evaluated. [Results] All patients were successfully operated on with operation time of (1.31±0.34) hours, and intraoperative blood loss of (103.33±32.41) ml. After more than 24 months of follow-up, VAS and ODI scores de- creased significantly compared with those preoperatively (P<0.05) . Radiographically, the anterior vertebral height of the involved vertebrae significantly increased (P<0.05) , whereas the local kyphotic Cobb angle significantly decreased postoperatively compared with those preop- eratively (P<0.05) . Compared with those at 2 weeks after surgery, the anterior vertebral height slightly decreased, while the local kyphosis Cobb angle increased at 24 months after surgery, which proved not statistically significant (P>0.05) . At the latest follow-up, no bone cement displacement, internal fixation loosening or fracture were found in anyone of them. [Conclusion] The vertebroplasty combined with pedicle screw fixation does achieve satisfactory clinical results in the treatment of stage III Kümmell’s disease.