Abstract:[Objective] To evaluate the significance of personalized combined gap balancing technique in total knee arthroplasty (TKA) . [Methods] A retrospective study was done on 68 patients who received TKA for knee osteoarthritis in our department from July 2019 to November 2019. According to the doctor-patient communication, 34 patients underwent TKA with personalized external rotation re- section of posterior femoral condyle combined with gap balancing technique (combined group) , while the remaining 34 patients had conven- tional posterior femoral condyle cutting at 3° external rotation (conventional group) . The perioperative, follow-up and imaging data of the two groups were compared. [Results] All patients in both groups were successfully operated on without obvious complications. The initial flexion gap imbalance was found in 3 cases of the combined group, whereas 11 cases in the conventional group, which proved statistically significant (P<0.05) . The combined group had significantly less perioperative blood loss than the conventional group (P<0.05) , although there were no significant differences in operative time, total incision length, intraoperative fluoroscopy times, ambulation time, incision heal- ing grade and hospital stay between the two groups (P>0.05) . With the follow-up time of (25.91±1.20) months, the VAS significantly de- creased (P<0.05) , while KSS score and ROM significantly increased in both groups (P<0.05) . There were no statistically significant differ- ences in the abovementioned indexes between the two groups preoperatively (P>0.05) . However, the combined group proved significantly superior to the conventional group in term of VAS score at 12 months after surgery and the last follow-up (P<0.05) , whereas KSS score and knee range of motion (ROM) at all matching time points postoperatively (P<0.05) . Radiographically, the femorotibial angle (FTA) and medi- al proximal tibial angle (MPTA) significantly improved in both groups postoperatively compared with those preoperatively (P<0.05) . Howev- er, there were no statistically significant differences in FTA, MPTA, α angle, β angle, sagittal femoral angle (SFA) and sagittal tibial angle (STA) between the two groups at any corresponding postoperative time points (P>0.05) . [Conclusion] The personalized external rotation re-section of posterior femoral condyle combined with gap balancing technique in total knee arthroplasty is beneficial to achieve gap balance of knee flexion, with better short-term clinical outcomes over the conventional posterior condyle resection in fixed 3° of external rotation.