Abstract:[Objective] To investigate the clinical outcomes of bone grafting combined with long oblique pedicle screw on the injured vertebrae in pedicle screw fixation of thoracolumbar burst fractures. [Methods] From February 2013 to February 2018, 42 patients under- went abovementioned surgical treatment for thoracolumbar burst fracture in our hospital. The perioperative, follow- up and imaging data were summarized. [Results] All the 42 patients were successfully operated on without serious complications. As time went during the fol- low-up lasted for (22.45±1.45) months, the VAS and ODI scores were significantly decreased (P<0.05) . In term of ASIA grade for neurolog- ical function, of the 12 cases who were grade B before operation, 8 cases improved to grade E and 4 cases to grade D at the latest follow-up, while all the 30 cases who were marked as grade C preoperatively recovered to grade E at the latest follow up (P<0.05) . Radiographically, the ratio of anterior height of injured vertebrae significantly increased (P<0.05) , while the local kyphotic Cobb's angle significantly de- creased postoperatively compared with those preoperatively (P<0.05) . [Conclusion] This bone grafting combined long oblique pedicle screw on the injured vertebrae in pedicle screw fixation of thoracolumbar burst fractures does improve nerve function, reconstruct the height of injured vertebrae, reduce residual kyphosis and maintain the correction effectively.