静脉联合鞘内抗菌药物治疗脊柱术后颅内感染△

Intravenous and intrathecal antibiotics for intracranial infection secondary to spinal surgery

摘要:

［目的］探讨静脉联合鞘内抗菌药物治疗脊柱术后颅内感染的疗效。［方法］9 例脊柱术后颅内感染患者采用静脉联合鞘内抗菌药物治疗，观察临床与检验结果。［结果］在治疗过程中，无脑出血、脑疝、神经损伤等严重并发症发生。所有患者均治疗平均 （2.22±1.39） d 后体温降至正常，静脉用药时间平均 （21.89±8.99） d，鞘内注射次数平均 （10.67±8.12） 次，均治愈出院，住院时间平均 （40.67±12.79） d。随访过程中无症状复发。检验方法，随时间推移，WBC、中性粒细胞比率、 CPR、ESR，以及 CSF 的 WBC 计数均显著降低 （P<0.05）。［结论］ 静脉联合鞘内抗菌药物治疗脊柱术后颅内感染可获得满意的临床效果。

Abstract:

[Objective] To explore the efficacy of intravenous and intrathecal antibiotics for intracranial infection secondary to spinal surgery. [Methods] A total of 9 patients with intracranial infection after spinal surgery were treated with intravenous and intrathecal antibi- otics. The clinical and laboratory results were observed. [Results] There were no serious complications such as cerebral hemorrhage, cere- bral hernia and nerve injury during the treatment. All the patients had temperature returned to normal in (2.22±1.39) days after treatment with intravenous administration for (21.89±8.99) days, and intrathecal injection of (10.67±8.12) times. All patients were cured and dis- charged with hospital stay of (40.67±12.79) days. No symptoms recurred in anyone of them during follow-up period. In terms of laboratory tests, the blood WBC count, neutrocyte ratio, CPR, ESR and WBC count of CSF significantly decreased over time (P＜0.05) . [Conclusion] The intravenous and intrathecal antibiotics do achieve satisfactory clinical results for intracranial infection secondary to spinal surgery.