Abstract:[Objective] To exlpore the efficacy and safety of unilateral biportal endoscopy (UBE) in the treatment of lumbar disc hernia- tion. [Methods] From January 2020 to August 2020, 36 patients, including 23 males and 13 females aged (39.30±13.90) years on a mean, were treated by UBE technique for lumbar disc herniation involving L3/4 in a case, L4/5 in 18 cases and L5S1 in 17 cases. The clinical and im- aging consequences were evaluated. [Results] All patients had UBE discectomy completed successfully with operation time of (89.19±35.20) min, postoperative drainage volume of (19.25±15.90) ml, and hospital stay of (3.53±2.14) days. All the patients had no serious intraoperative complications, except one patient who got nerve root injury that not lead serious consequence. As time went during the follow up period last- ed for (4.30±1.23) months, the low back pain and leg pain VAS scores, as well as Oswestry index significantly improved (P<0.05) . According to the modified Macnab’s criteria, the excellent and good rate of clinical results was of 91.67%. Radiographically, a significant decrease of the intervertebral height, whereas a significant enlargement of spinal canal area was found at the latest follow up compared with those preop- eratively (P<0.05) . [Conclusion] The UBE technique has a character of relatively easy to be mastered, is a safe and feasible method for the treatment of lumbar disc herniation.