Abstract:[Objective] To explore the short-term clinical outcomes of decompression and unilateral non-fusion pedicle screw fixation by the Quadrant channel for lumbar disc herniation. [Methods] From January 2017 to April 2019, a total of 50 patients underwent abovemen- tioned surgical treatment for lumbar disc herniation complicated with or without unilateral lateral recess stenosis, including 42 cases with sin- gle level involved and 8 cases with double levels affected. The perioperative and follow-up results were analyzed. [Results] All patients were successfully operated on without serious complications. Although the single- segment group had significantly less operative time, incision length, intraoperative fluoroscopy times and postoperative drainage than the double-segment group (P<0.05) , there were no significant dif- ferences in postoperative ambulation time and hospital stay between the two groups (P>0.05) . As time went during the follow-up lasted for (21.83±6.87) months, the VAS scores for low back pain and leg pain, as well as the ODI score significantly decreased (P<0.05) . The clinical results were graded as excellent in 41 cases, good in 6 cases and fair in 3 cases, with the excellent and good rate of 94.00% at the latest fol- low-up. [Conclusion] The decompression and unilateral non-fusion pedicle screw fixation by the Quadrant channel do achieve satisfactory short-term outcomes for lumbar disc herniation with or without unilateral recess stenosis with minimizing iatrogenic trauma, however the long-term consequence needs further observation.