Abstract:[Objective] To compare the clinical outcomes of femoral neck system (FNS) versus cannulated screw (CS) for femoral neck fractures in young and middle- aged. [Methods] A retrospective study was conducted on 137 young and middle- aged patients who had been surgically treated for femoral neck fracture at our hospital from June 2019 to January 2021. Based on preoperative doctor-patient com- munication, 64 patients had the fractures fixed with FNS, while the remaining 73 patients were with CS. The perioperative, follow-up and imaging data were compared between the two groups. [Results] All patients in both groups had operation performed smoothly without seri- ous complication. The FNS group proved significantly superior to the CS group in terms of operation time, fluoroscopy frequency, postopera- tive partial weight-bearing time, as well as VAS scores at 3, 7, and 30 days postoperatively (P<0.05) . All the patients in both groups were followed up for more than 12 months, and the revision surgery of total hip arthroplasty was performed in 1 case only (1.56%) in the FNS group, whereas 2 cases (2.7%) in the CS group. The Harris score, flexion-extension and internal-external rotation range of motions of the hip (ROMs) increased significantly in both groups over time postoperatively (P<0.05) , which in the FNS group proved significantly superior to those in the CS group at all corresponding time points (P<0.05) . With respect to radiographic evaluation, although there were no signifi- cant differences in term of Garden index, neck shortening and neck-shaft angle between the two groups immediately postoperatively (P> 0.05) , the FNS group proved significantly superior to the CS group in terms of radiographic fracture healing time, as well as femoral neck shortening, neck-shaft angle and internal fixation loosening at the latest follow up (P<0.05) . [Conclusion] The FNS has an advantage of firm fixation of the fracture, which facilitates fracture healing and functional recovery for femoral neck fractures in young and middle-aged over the CS.