Abstract:[Objective] To compare the clinical outcomes of pedicle screw fixation with or without screw placement in the fractured ver- tebrae for simple thoracolumbar burst fractures. [Methods] A retrospective study was done on 96 patients who underwent surgical treatment for simple thoracolumbar burst fracture in our hospital from March 2017 to March 2020. According to the results of doctor-patient commu- nication preoperatively, 50 patients had pedicle screw fixation performed with screw placement at the fractured vertebrae (the SPFV group) , while the remaining 46 patients received pedicle screw fixation without screw placement at the fractured vertebrae (the non-SPFV group) . The documents regarding to perioperative period, follow-up and radiographs were compared between the two groups. [Results] All the patients in both groups were operated on successfully without serious complications. Although the SPFV group consumed operative time, intraoperative blood loss, and incisive length significantly greater than the non-SPFV group (P<0.001) , the former resumed postopera- tive ambulation significantly earlier, associated with significantly shorter hospital stay than the latter (P<0.001) . All patients were followed up for (15.52±3.41) months, and the SPFV group recovered full weight-bearing activity significantly earlier than the non-SPFV group (P< 0.001) . VAS and ODI scores decreased significantly over time in both groups (P<0.001) . There were no statistically significant differences in VAS and ODI scores between the two groups before surgery (P>0.05) , however, the SPFV group proved significantly superior to the nonSPFV group in the VAS and ODI scores postoperatively (P<0.001) . Radiographically, the anterior height ratio of the injured vertebrae sig- nificantly increased (P<0.001) , while the local kyphotic Cobb's angle significantly decreased postoperatively compared with those preopera- tively in both groups (P<0.001) . Nevertheless there were no statistically significant differences in the anterior height ratio of the injured ver- tebrae and local kyphotic Cobb's angle between the two groups before operation (P>0.05) . Campared with those at 3 days after operation and the last follow-up, the above imaging indexes were lost in both groups, which proved not statistically significant in the SPFV group (P> 0.05) , whereas statistically significant in term of anterior height ration of the injured vertebrae in the non-SPFV group (P<0.05) . [Conclusion] The pedicle screw fixation with SPFV is considerably superior to that without SPFV in traditional way in terms of fracture reduction quality and fixation stability for simple thoracolumbar fractures.