内源性神经干细胞在脊髓损伤修复的研究进展△

Research Progress in endogenous neural stem cells in spinal cord injury repair

摘要:

内源性神经干细胞 (endogenous neural stem cells, ENSCs) 在脊髓损伤 (spinal cord injury, SCI) 后可以分化为星形胶质细胞、神经元和少突胶质细胞等，对神经再生具有重要作用。研究诱导其分化为特定的神经细胞的方法是内源性治疗的关键。近年来，越来越多的 ENSCs 诱导方法被开发运用，促进了新生神经元和少突胶质细胞的生成，并减少了胶质瘢痕对修复的阻碍作用。本文就近期 ENSCs 在 SCI 修复方面的研究进展进行综述。

Abstract:

Endogenous neural stem cells (ENSCs) can differentiate into astrocytes, neurons and oligodendrocytes after spinal cord inju- ry (SCI) , and play an important role in nerve regeneration. The key to endogenous therapy is to induce its differentiation into specific nerve cells. In recent years, more and more ENSCs induction methods have been developed and applied to promote the formation of new neurons and oligodendrocytes to reduce the hindering effect of glial scar on repair. This paper reviews the recent progress of ENSCs in SCI repair.