Abstract:[Objective] To investigate the clinical outcomes of arthroscopic repair with single row anchors for large rotator cuff tears. [Methods] A total of 24 patients underwent arthroscopic repair with single row metal anchors for large rotator cuff tears 3 to 5 cm in size from January 2019 to June 2020. The perioperative and follow-up documents were evaluated. [Results] All the patients were operated on smoothly without intraoperative neurovascular injuries, whereas with operation time of (68.22 ± 16.67) min, intraoperative blood loss of (15.09±4.27) ml, implant used of (2.94±0.23) anchors, and well incision healing. Of them, 22 patients were followed up for (18.87±4.99) months, with the time to resume full weight bearing activity of (3.83±1.02) months. The VAS and UCLA scores significantly improved at the latest follow up compared with those preoperatively (P<0.05) . All the patients recovered well in term of shoulder function without night pain. MRI showed excellent rotator cuff healing without pullout of the anchor in all the patients, except 2 patients who were found retear of the rotator cuff. [Conclusion] Arthroscopic repair with single row anchors for large rotator cuff tear has the advantages of simplifying opera- tion, shortening operation time, satisfactory outcome, decreasing financial cost and declining the learning curve.