Abstract:[Objective] To evaluate the significance of enhanced recovery after surgery (ERAS) applied by a team integrated with sur- geon, nurse and rehabilitator in perioperative period of total knee arthroplasty (TKA) for rheumatoid arthritis. [Methods] From November 2019 to September 2021, 84 patients received TKA for rheumatoid arthritis, and were divided into two groups by random number table method. The ERAS was used in 42 cases, while conventional treatment was used in the other 42 cases. The early clinical and laboratory da- ta were compared between the two groups. [Results] The ERAS group prove sifnificanlty superior to the conventional group in terms of the time of getting out of bed and hospital stay (P<0.001) . The ERAS group was significantly superior to the conventional group in terms of HSS scores at 2 weeks, 6 weeks and 6 months after surgery (P<0.05) , VAS scores at 2 and 6 weeks postoperatively (P<0.05) . In terms of blood testing, the ERAS group had significantly lower levels of D-D, FIB, ESR and CRP at 1 and 3 days postoperatively. [Conclusion] The integrated ERAS does significantly relieve perioperative pain, accelerate knee functional recovery, improve clinical coagulation and inflam- mation markers, and shorten hospitalization time in TKA for rheumatoid arthritis.