Abstract:Abstract Objective Prospective study on the effect of pericapsular nerve group block on analgesia and rapid rehabilitation after total hip arthroplasty. Methods From June 2020 to September 2021, 108 patients with total hip arthroplasty were randomly divided into experimental group (pericapsular nerve group block, PNGB) and control group ( fascia iliaca compartment block, FIC), including 54 cases in experimental group and 55 cases in control group. The operation time, intraoperative bleeding, first landing time and hospital stay were compared; Visual analog pain score(VAS), quadriceps femoris muscle strength, dosage of patient-controlled intravenous analgesia (PCIA), Postoperative nausea and vomiting(PONV) before and 12 hours, 24 hours and 36 hours after operation.Results ① there was no significant difference in operation time, intraoperative bleeding and hospital stay (P > 0.05). ② At 12h and 24h after operation, the VAS of the experimental group was significantly lower than that of the control group (P < 0.001). At 36h , there was no significant difference between the two groups (P > 0.05). The dosage of PCIA in the experimental group was significantly lower than that in the control group at 12h and 24h after operation (P < 0.001). At 12 hours ,the muscle strength of quadriceps femoris in experimental group was significantly higher than control group (P < 0.001). ③ PONV occurred in 25 patients after operation, including 8 (14.81%) in the experimental group and 17 (30.91%) in the control group,the difference was significant (P<0.05)..Conclusion Periarticular capsule nerve block can relieve the pain after total hip replacement and reduce the dosage of opioids. The analgesic effect is better than that of iliac fascia compartment block