Abstract:[Objective] To investigate the characteristics and management results of complications of open reduction and plate internal fixation for proximal humeral fractures. [Methods] From January 2018 to January 2021, a total of 114 patients received open reduction and plate internal fixation for proximal humeral fractures in our hospital. The occurrence, characteristics, management and outcome of complica- tions were assayed in this arthicle. [Results] Among 114 patients, 32/114 (28.1%) had late complications, including poor fracture reduction 8/114 (7.0%) , poor internal fixation position 7/114 (6.1%) , loose internal fixation 5/114 (4.4%) , malunion 4/114 (3.5%) , subacromial im- pact 4/114 (3.5%) , femoral head necrosis 2/114 (1.8%) , incision malunion 1/114 (0.9%), infection 1/114 (0.9%), which proved statistically significant in term of the incidence of various complications (P<0.05) . In term of fracture classification, the total complication rate was of 4/ 16 (25.0%) in the two-part fracture, 17/82 (20.7%) in the three-part fracture, 7/8 (87.5%) in the four-part fracture and 4/8 (50.0%) in the fracture dislocation, with a significantly difference among them (P<0.05) . After corresponding treatment, all patients had no serious adverse consequences. Of them, 12 patients had no pain at all, 15 patients had mild pain during activities, and 5 patients had obvious pain; 10 pa- tients had on shoulder motion affected, 18 cases got mildly limited, and 4 cases had significantly limited motion; 14 cases regained sports and labor capacity to the levels before injury, while 18 cases were under the levels at the latest follow-up. [Conclusion] The complications of open reduction plate internal fixation of proximal humerus fractures are as high as 13.2%, and the most common complications are loosen- ing of internal fixation, malunion and subacromial impingement, which should be paid more attention to.