Abstract:[Objective] To investigate the characteristics and management results of complications secondary to open reduction and in- ternal fixation (ORIF) of clavicle fractures. [Methods] A retrospective study was conducted on 228 patients who received ORIF of clavicle fractures in our hospital from January 2019 to December 2020. The occurrence, characteristics, management and outcome of complications were analyzed in this paper. [Results] Among 228 patients, 19 patients suffered from complications, accounting for 8.33%. In term of time of complication happened, the early complications were found in 6 cases, accounting for 31.57%, while late complications were seen in 13 cases, accounting for 68.4%, which was statistically significant (P=0.001) . In term of fracture site, the complication rate was 4/57(7.0%) in the lateral clavicle, 15/161 (9.3%) in the middle part of clavicle, 0/5 (0.0%) in the medial clavicle, whereas 0/5 (0.0%) in bipolar fracture with a statistically significant difference among the 4 parts (P=0.023) . In term of the internal fixation method, the complication rate proved 3/20 (15.0%) in the clavicle hook plate, 1/15 (9.3%) in the lateral end plate combined with the coracoclavicular suspension, 0/22 (0.0%) in the simple lateral end plate, 15/161 (9.3%) in mid-clavicle plate, while 0/5 (0.0%) in medial clavicle plate, which was statistically signifi- cant (P=0.036) . The incidence of specific complications ranked from high to low was of refracture after removal of internal fixation (7/19, 36.8%) , fracture of internal fixation (6/19, 31.6%) , incision infection (3/19, 15.8%) , irritation of internal fixation (1/19, 5.3%) and acromio- clavicular dislocation (1/19, 5.3%) with significant differences in the incidence of various complications (P=0.018) . Of the 19 patients, 4 cases were treated conservatively, whereas15 cases underwent revision surgery without serious adverse events. Of them, 15 patients had no pain at all, 3 patients had mild pain during activities, and 1 patients had obvious pain; 10 patients had no shoulder motion affected, 6 cases got mildly limited, and 3 case had significantly limited motion; 13 cases regained sports and labor capacity to the levels before injury, while 6 cases were under the levels at the latest follow-up. [Conclusion] Although ORIF of clavicle fractures is a routine operation, the complica- tion rate is still as high as 8.33%, including the most common complications of refracture after removal of internal fixation, fracture of inter- nal fixation and infection. Improving surgical technique is the key to reduce complications.