Abstract:[Objective] This paper describes the surgical techniques and preliminary clinical results of Endoscope-Anterior Cervical Discectomy and Fusion (Endo-ACDF).[Methods] From January 2021 to February 2023,15 patients with cervical myelopathy were treated with Endo-ACDF. The intervertebral disc tissue, vertebral osteophytes and posterior longitudinal ligament protruding into the spinal canal were removed endoscopically to determine that the anterior dural membrane was completely reduced without compression, and the dural beat was restored. The vertebral space was extended with the open device, and the cage was implanted into the vertebral space.[Results] All patients completed the procedure successfully without serious intraoperative complications. During the postoperative follow-up of 6 to 12 months, the postoperative VAS score of axial pain and NDI score were significantly lower (P <0.001), and the cervical JOA score was significantly higher (P <0.001). After surgery, cervical imaging was reviewed, cervical internal fixation and disc surgery, and the dural and nerve roots were completely decompression.[Conclusion] Endo-ACDF provides the treatment of cervical myelopathy with clear visual surgical vision, and is an accurate, safe and reliable surgical method that can achieve sufficient decompression, with satisfactory short-term efficacy.