Abstract:[Objective] To compare the clinical outcomes of femoral neck system versus cannulated compression screws for femoral neck fracture in young and middle- aged patients by a meta- analysis. [Methods] The electronic databases were searched before March 2022, including PubMed, Embase, Cochrane Library, Wanfang, CNKI, and VIP databases for published researches on FNS versus CCS for femoral neck fracture. RevMan 5.4 software was used to conduct meta-analysis of the data. [Results] A total of 10 articles were included into this study, involving 324 patients who had FNS used, while 374 patients who had CCS performed. As results of the meta-analysis, the FNS group proved significantly superior to the CCS group in terms of the fluoroscopy frequency, postoperative weight-bearing time, fracture heal- ing time, femoral neck shortening length, and Harris score (P<0.05) , whereas the FNS group was significantly inferior to the CCS group in the intraoperative blood loss and incision length (P<0.05) . In addition, the FNS group was significantly superior to the CCS group in terms of occurrence of internal fixation failure and the femoral neck shortening (P<0.05) . However, there were no significant differences in operation time, hospital stay, incidences of nonunion and avascular necrosis of the femoral head between the two groups (P>0.05) . [Conclusion] The FNS takes advantages of earlier postoperative weight-bearing activity, earlier fracture healing, lower incidences of femoral neck shortening and internal fixation failure over the CCS for internal fixation of femoral neck fractures in young and the middle-aged, and is beneficial to re- cover the hip functional capacity.