Abstract:[Objective] To evaluate the imaging measurement, pathological mechanism and clinical significance of coronal tibiofemoral subluxation (CTFS) . [Methods] As PubMed, Embase, Cochrane Library, Web of Science and other international medical databases were searched with "tibiofemoral", "tibial and femoral", "instability", "subluxation", "dislocation" and "CTFS" as the key words, the related litera- tures were selected manually according to the inclusion criteria. [Results] A total of 18 articles were included, of which 16 reported imaging measurement methods, 6 reported mechanism and risk factors, and 10 reported clinical issues. At present, there is no unified standard for Xray measurement of CTFS, while there are few studies on the mechanism of CTFS still with controversies. Currently, the accepted theory is that the lateral ligament structure of the knee joint is relatively relaxed. CTFS is a common radiographic manifestation of KOA, but is not of value in determining the severity of KOA. In terms of clinical symptoms, current research is still controversial. [Conclusion] The mainstream view of CTFS is that it is not related to the severity of KOA. However, attention should be paid to this problem in the stepwise treatment of knee osteoarthritis to avoid complications due to poor ligament stability.