细胞衰老在激素性骨质疏松症中的作用

Role of cell senescence in glucocorticoid-induced osteoporosis

摘要:

糖皮质激素(glucocorticoid, GC)被广泛应用于内科疾病的治疗，但其副作用，尤其是激素诱导性骨质疏松症(glu- cocorticoid-induced osteoporosis, GIOP) 仍是一个严重的临床问题。目前，GIOP 的实际机制仍不清楚，但最新研究表明其与应激等因素导致的细胞衰老密切相关，也就是说细胞衰老可能是 GIOP 的一种形成机制。激素通过诱导骨组织细胞衰老，衰老细胞旁分泌衰老相关因子 (senescence-associated secreted phenotype, SASP)，产生细胞衰老的级联放大反应，最终形成 GIOP。本文就细胞衰老与 GIOP 的关系、相关机制以及靶向阻断措施等方面进行综述。

Abstract:

Glucocorticoid (GC) has been widely used in the treatment of internal diseases. However, glucocorticoid-induced osteoporo- sis (GIOP) , one of GC adverse effects, is still a serious clinical problem. Currently, the mechanism of GIOP remains unclear, but recent stud- ies show that it might be closely related to cell senescence caused by stress and other factors, in other word, cell senescence may be involving pathogenesis of GIOP. The glucocorticoid induces the senescence of bone tissue cells, and then the senescent cells secrete senescence-asso- ciated secreted phenotype (SASP) by paracrine to produce the cascade amplification reaction of cell senescence and finally form GIOP. This article reviews the relationship between cell senescence and GIOP, related mechanisms and targeted blocking measures.