Abstract:[Objective] To explore the clinical outcomes arthroscopic reduction and internal fixation (ARIF) through the anterolateral approach for treatment of tibial plateau fractures. [Methods] A retrospective study was done on 95 patients who underwent surgical treat- ment for tibial plateau fractures from January 2018 to January 2020 in our hospital. Among them, 49 patients receive ARIF through antero- lateral approach, while the remaining 46 patients were treated with conventional open reduction and internal fixation (ORIF) according to the consequence of preoperative patient-doctor communication. The perioperative conditions, follow-up results and imaging data were com- pared between the two groups. [Results] All patients in both groups were successfully operated on without iatrogenic injuries to important blood vessels, nerves and meniscus. The ARIF group proved significantly superior to the ORIF group in terms of incision length, operative time, intraoperative blood loss, frequency of fluoroscopy, postoperative drainage, time to return ambulation with crutches, hospital stay and VAS score 3 days postoperatively (P<0.05) . All patients in both groups were followed up for 12~24 months, with an average of (16.5±3.6) months. Adverse events were 1/49 (2.0%) in the ARIF group, whereas 8/46 (17.4%) in the ORIF group, which was statistically significant (P<0.05) . The ARIF group resumed full weight-bearing activity significantly earlier than the ORIF group (P<0.05) . In addition, the ARIF group was significantly superior to the ORIF group in terms of HSS, Lysholm and Rasmussen function scores, as well as knee flexion and ex- tension range of motions (ROMs) at 3 months and the latest follow-up (P<0.05) . Regarding to radiographic evaluation, the ARIF group had significantly higher Rasmussen anatomical scores than the ORIF group immediately after surgery and at the latest follow-up (P<0.05) . The articular surface collapse was significantly reduced in both groups immediately after surgery and at the last follow-up compared with those before operation (P<0.05) , whereas which in the ARIF group were significantly less than those in the ORIF group immediately after surgery and at the latest follow-up (P<0.05) . [Conclusion] The arthroscopic reduction and internal fixation is considerably superior to the conven- tional open reduction and internal fixation in term of clinical outcomes for tibial plateau fractures