白细胞介素在椎间盘退变中的作用△

Role of interleukin in intervertebral disc degeneration

摘要:

椎间盘退变引起的下腰痛严重影响着老年患者的健康，同样也给社会和家庭带来巨大的负担。椎间盘退变从 18 岁开始，由于年龄、生物力学、生物化学、自身免疫炎症反应和遗传易感等因素的影响，加速椎间盘退变的过程。椎间盘退变是一个序贯、级联发生的病理过程，从椎间盘细胞微环境的改变开始，发展为椎间盘结构和功能的改变，其主要病理特征是炎症细胞因子，如白细胞介素 (interleukins, ILs) 的释放，促分解代谢酶的表达增加，细胞外基质降解，椎间盘细胞凋亡等。在椎间盘退变过程中白细胞介素起到了重要作用，本文将对白细胞介素在椎间盘退变中的作用进行综述。

Abstract:

Low back pain caused by intervertebral disc degeneration seriously affects the health of elderly patients, but also brings a huge burden to society and family. Intervertebral disc degeneration begins at age 18, and is accelerated by the age, with biomechanics, bio- chemistry, autoimmune inflammatory response and genetic predisposition factors. Intervertebral disc degeneration is a sequential, cascade pathological process that starts with changes in the microenvironment of intervertebral disc cells and progresses to changes in intervertebral disc structure and function. A major pathological feature is the release of inflammatory cytokines such as interleukin, which increased ex- pression of catabolic enzymes, degradation of extracellular matrix, and intervertebral disc cell apoptosis. As interleukins (ILs) plays an im- portant role in intervertebral disc degeneration, this article reviews the effect of interleukin on intervertebral disc degeneration.