Abstract:[Objective] Explore the Frosch approach exposure method and open reduction strategy for 3D printing assisted posterior lateral tibial plateau fractures. [Methods] Retrospective analysis of 43 patients who underwent surgical treatment for posterior lateral tibial plateau fractures from January 2021 to February 2022. According to the results of preoperative doctor-patient communication, 21 cases were treated with 3D printing assisted open reduction and internal fixation through the Frosch approach, while 22 cases were treated with conventional open reduction and internal fixation through both the anterior lateral and posterior lateral (Carlson) approaches. Compare the perioperative, follow-up, and imaging indicators between the two groups. [Results] Both groups of patients underwent surgery successfully. There was no statistically significant difference (P>0.05) between the two groups in terms of surgical time, total length of the surgical site, intraoperative blood loss, intraoperative fluoroscopy frequency, hospital stay, intraoperative complications, and fracture reduction quality. The Frosch group had earlier walking time in the ground than the around group, and the difference was statistically significant (P<0.05). Both groups of patients achieved satisfactory knee joint function at 3, 6, and 12 months after surgery. The HSS knee joint function score in the Frosch group was higher than that in the around group, and the difference was statistically significant (P<0.05),The ROM of knee joint flexion and extension activity in the Frosch group was higher than that in the around group, and the difference was statistically significant (P<0.05). while the around group experienced 2 cases of local ischemic necrosis of the surgical flap, which healed after dressing change. [Conclusion] 3D printing assistance involves the Frosch approach for tibial posterolateral plateau fractures, which can be reduced under direct vision, effectively restoring the joint surface, facilitating internal fixation placement, reducing intraoperative complications, early mobilization, and better functional recovery.