Abstract:Abstract: The communication between the brain and the spinal cord's regulatory nerve circuits is disrupted by spinal cord injury (SCI). As a result, there is sensory loss, lifelong paralysis, and autonomic dysfunction. The majority of the nerve circuits above and inferior to the foci of spinal cord injury, however, are physically unharmed, and the aforementioned nerve circuits can convey motor impulses via relay nerve loops down to the injured spinal cord regions. Therefore, one of the most promising therapeutic approaches to enhance functional recovery following SCI is the restoration of relay neuronal circuits. Moreover, the neuromodulation technique is able to utilize residual brain, brainstem and spinal cord neurons to reconstruct the spinal relay neural circuit and improve neurological function after SCI. In order to understand the progress of neuromodulation to reconstructs the spinal relay neural circuit.The repair of relay neuronal networks in the cortex, brainstem, and spinal cord following SCI is summarized in this article. Further discussion is given to the potential mechanisms and effects of neuromodulation of the pertinent brain circuits following SCI.