延缓椎间盘退变抗衰老疗法的研究进展

Research progress of anti-aging therapy to delay intervertebral disc degeneration

摘要:

随着年龄的增长，椎间盘退变（Intervertebral Disc Degeneration，IVDD）是导致腰痛的重要原因，给社会带来了巨大的经济负担。而退变的关键始动因素被认为是细胞衰老，许多内在（炎症反应、氧化应激、线粒体功能障碍、端粒缩短、DNA 损伤、营养剥夺和表观遗传学改变等）和外在因素（急性椎间盘损伤、过度机械载荷和长期吸烟等）已被证明促进了椎间盘细胞的衰老。本文总结椎间盘细胞的相关研究进展汇总了近年来一些针对抗衰老的干预措施在延缓椎间盘细胞衰老中的作用，包括衰老细胞清除、抗炎、抗氧化应激、端粒酶转导、生长因子供应和阻断细胞周期抑制剂等，这些措施为延缓IVDD提供了新的治疗策略。

Abstract:

Intervertebral Disc Degeneration (IVDD) is the main cause of low back pain with increasing age, and brings a huge economic burden to society. The key initiating agent of degeneration is often considered to be cellular aging, which has been promoted by many intrinsic (inflammatory responses, oxidative stress, mitochondrial dysfunction, telomere shortening, DNA damage, nutritional deprivation and epigenetic changes) and extrinsic (acute intervertebral disc injury, excessive mechanical loading and chronic smoking) factors. In this study, we attempt to elucidate the changes and extracellular microenvironment related to cell aging in intervertebral disc, and summarize the role of some current anti-aging interventions in delaying cell aging in intervertebral disc, including senolytic, anti-inflammatory and antioxidant stress, telomerase transduction, growth factor supply and cell cycle blocking inhibitors, etc. These interventions may play an important role in delaying IVDD.