Abstract:[Objective] To evaluate the clinical efficacy of surgical treatment of foot and ankle gout. [Methods] Thirty-eight patients with gout in the foot and ankle who underwent surgical treatment from December 2016 to June 2022 were reviewed; preoperative, 3-month postoperative, and final follow-up blood uric acid levels, frequency of gouty attacks, and visual analogue scale (VAS) for evaluating pain relief and uric acid control were observed and compared; Observe and compare the ankle function of patients with American Orthopedic Foot & Ankle Society (AOFAS) ankle-hindfoot scores at preoperative, 3 months postoperative and final follow-up; results: 38 patients were followed up for 6-12 months, with satisfactory correction of deformity and recovery of motor function, and the VAS scores at the final follow-up were decreased from preoperative ( 6.3±1.1) to (2.0±0.5), the frequency of gouty attacks decreased from preoperative (3.5±0.9)/month to (0.8±0.4)/month, the blood uric acid level decreased from preoperative (586.8±90)μmol/L to (392.1±21.5)μmol/L, and the AOFAS score increased from preoperative (64.6±4.5) to (79.1±3.6) points (P<0.05). [Conclusion] Surgical cleanup of foot and ankle gout can significantly reduce and control uric acid levels, effectively relieve pain and improve ankle function, with good clinical efficacy.