脊柱布氏杆菌病炎性因子变化的研究现状

Research progress of macrophage polarization and related inflammatory factors in brucellosis spondylitis

摘要:

布鲁氏菌病主要造成骨与关节损害，最常见的就是布鲁氏菌性脊柱炎 (简称布病脊柱炎)。一旦发生布鲁氏菌感染，布鲁氏菌主要被人体内巨噬细胞吞噬，并寄生在宿主的巨噬细胞内，引起巨噬细胞极化释放相关炎症因子：如肿瘤坏死因子-α (tumor necrosis factor-α, TNF-α)、白介素因子家族(interleukins, IL)趋化因子家族(chemokines)。研究表明这些炎症因子在布病脊柱炎的炎症和骨质破坏中起到了重要作用。同时，不同极化类型的巨噬细胞转化可调控炎症和骨破坏的发生及发展方向。本文将对巨噬细胞极化相关炎症因子在布病脊柱炎发病机制中可能的作用机制作一综述。

Abstract:

Brucellosis usually leads bone and joint damage, the most common of which is Brucellosis spondylitis. Once Brucella infec- tion occurs, the Brucella is mainly swallowed by human macrophages and parasitized in host macrophages, causing macrophages to release related inflammatory factors in polarization, such as tumor necrosis factor -α (TNF-α) , interleukin factor family (IL) and chemokines family. Many researches have showed that these inflammatory factors play an important role in inflammation and bone destruction of brucellosis spondylitis. At the same time, the transformation of macrophages with different polarization types can regulate the occurrence and develop- ment direction of inflammation and bone destruction. This article reviewed the possible mechanism of macrophage polarization-related in- flammatory factors in the pathogenesis of brucellosis spondylitis.