关节内注射脐带血单个核细胞治疗膝骨关节炎
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靳文舒,硕士研究生,研究方向:骨关节炎的相关基础和临床研究,(电话)15666258552,(电子信箱)jin15666258552@163.com

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R681.57

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山东省自然科学基金项目(编号:ZR2019MH130)


Intra- articular injection of umbilical cord blood mononuclear cells for treatment of knee osteoarthritis
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    摘要:

    目的] 探讨脐带血单个核细胞 (umbilical cord blood mononuclear cells, UCB-MNCs) 治疗膝关节骨关节炎 (knee os- teoarthritis, KOA)的临床疗效和安全性。[方法]2021 年 2 月—2022 年 9 月,30 例早、中期 KOA 患者接受膝关节腔内注射 2× 108 (3 ml)UCB-MNCs 治疗 2 次,间隔 1 个月。评估临床与影像资料。[结果]所有患者均顺利完成注射,主要不良反应为注射数天内关节肿胀和疼痛,但不影响关节功能活动。治疗前后血常规、血沉、C 反应蛋白以及肝功能、肾功能均无显著变化。随访 6 个月以上,随时间推移,患者疼痛和肿胀的 VAS 评分,以及 WOMAC 的疼痛、僵硬、功能、总体评分均显著降低(P<0.05), 而 KOOS 各子项评分均显著提高(P<0.05)。影像方面,与治疗前相比,治疗 3 个月后 X 线片显示内侧、外侧和髌股室的 K-L 评级均无显著变化 (P>0.05);内侧室 MOAKS 无显著变化 (P>0.05),而外侧室和髌股室 MOAKS 显著下降 (P<0.05)。[结论] KOA 患者膝关节腔内注射 UCB-MNCs 治疗能有效缓解疼痛,改善功能。

    Abstract:

    [Objective] To explore the clinical efficacy and safety of intra-articular injection of umbilical cord blood mononuclear cells (UCB-MNCs) for treatment of knee osteoarthritis (KOA) . [Methods] From February 2021 to September 2022, 30 patients received intraven- tricular injection of 2×108 (3 ml) UCB-MNCs twice with one month apart for early- and mid-stage KOA. The clinical and imaging data were evaluated. [Results] All the patients had the injection completed successfully, with the main adverse reactions of joint swelling and pain with- in a few days after injection, whereas which not affected functional activities of the joint. There were no significant changes in blood routine, erythrocyte sedimentation, C-reactive protein, liver function and kidney function before and after treatment. As time went during the followup lasted for 6 months, the VAS scores for pain and swelling, as well as WOMAC pain, stiffness, function, and overall scores significantly de- creased (P<0.05) , while all KOOS subscores significantly increased (P<0.05) . Radiographically, the Kellgren-Lawrence grades in the medi- al, lateral and patellofemoral compartments remained unchanged (P>0.05) , the MRI Osteoarthritis Knee Score (MOAKS) of the medial com- partment was not changed either (P>0.05) , while the MOAKS scores of the lateral and patellofemoral compartments significantly decreased 3 months after treatment compared with those before treatment (P<0.05) . [Conclusion] Intra-articular injection of UCB-MNCs for KOA does effectively relieve pain and improve function in this trial.

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靳文舒,王哲,岳耀辉,等. 关节内注射脐带血单个核细胞治疗膝骨关节炎[J]. 中国矫形外科杂志, 2023, 31 (6): 555-558. DOI:10.3977/j. issn.1005-8478.2023.06.16.
JIN Wen- shu, WANG Zhe, YUE Yao-hui, et al. Intra- articular injection of umbilical cord blood mononuclear cells for treatment of knee osteoarthritis[J]. ORTHOPEDIC JOURNAL OF CHINA , 2023, 31 (6): 555-558. DOI:10.3977/j. issn.1005-8478.2023.06.16.

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  • 收稿日期:2022-09-28
  • 最后修改日期:2022-12-29
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  • 在线发布日期: 2023-03-27
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